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目的:观察睫状体无色素上皮腺瘤(ANPCE)的超声影像特征。方法:回顾性病例对照研究。2014年1月至2021年10月于首都医科大学附属北京同仁医院眼科中心检查确诊的ANPCE患者31例31只眼(ANPCE组)以及同期检查确诊的睫状体黑色素瘤患者17例17只眼(对照组)纳入研究。两组患者年龄(n t=-0.564 )、性别构成比(n χ2 =0.182)比较,差异均无统计学意义(n P=0.576、0.670)。采用超声生物显微镜测量肿瘤高度、最大基底径、最大径、最大径与基底径比值及最大径与高度比值。观察肿瘤位置、形态、内回声强度、回声均匀性、声衰减程度、是否侵犯虹膜、继发虹膜膨隆、晶状体不全脱位等。两组患眼测量参数及观察指标比较采用独立样本n t检验或χn 2检验。绘制受试者工作特征(ROC)曲线,确定ROC曲线下面积(AUC),筛选有鉴别诊断价值的参数指标。n 结果:ANPCE组、对照组患眼肿瘤最大径、高度、最大基底径、最大径与最大基底径比值、最大径与高度比值分别为(5.64±0.98) mm、(4.24±0.59)mm、(3.66± 0.71)mm、1.58±0.34、1.34±0.19和(7.82±2.03)mm、(4.47±2.44)mm、(7.02±1.96)mm、1.13±0.16、2.09±1.06. ANPCE组肿瘤最大径、最大基底径、最大径与高度比值均小于对照组,最大径与最大基底径比值大于对照组,差异均有统计学意义(n t=-4.159、-6.808、-2.924、6.257,n P<0.05 )。ANPCE组肿瘤主要表现为球形(87.1%,27/31)、声衰减不显著(77.4%,24/31 )、较少侵犯根部虹膜(77.4%,24/31)、瘤体多位于睫状体冠部(74.2%,23/31);对照组肿瘤主要表现为半球形(47.1%,8/17)或球形(47.1%,8/17)、声衰减显著(76.5%,13/17)、多侵犯虹膜(70.6%,12/17)、瘤体多位于睫状体平坦部至冠部(76.5%,13/17)。两组患眼间肿瘤基底部位置、形态、声衰减程度、是否侵犯虹膜比较,差异均有统计学意义(n χ2=15.132、19.767、13.118、10.581,n P<0.05)。ROC曲线分析结果显示,最大径与最大基底径比值,声衰减程度和是否侵犯虹膜的AUC较高,分别为0.881、0.769、0.740。n 结论:超声生物显微镜对ANPCE和睫状体黑色素瘤的诊断与鉴别诊断有一定帮助;肿瘤最大径与最大基底径比值、声衰减程度、是否侵犯根部虹膜是鉴别两种肿瘤的重要参数指标。“,”Objective:To analyze the ultrasonographic features of adenoma of the nonpigmented ciliary epithelium (ANPCE).Methods:A retrospective series of case studies. From January 2014 to October 2021, 31 patients (31 eyes) with ANPCE (ANPCE group) were diagnosed in the eye center of Beijing Tongren Eye Center of Beijing Tongren Hospital, Capital Medical University, and 17 patients (17 eyes) with ciliary body melanoma (control group) diagnosed at the same time were selected as the control group. There was no significant difference in age (n t=-0.564) and sex composition ratio (n χn 2=0.182) between the two groups (n P=0.576, 0.670). All patients underwent ultrasound biomicroscopy to obtain the measurement parameters: tumor height, maximum basal diameter, maximum diameter, ratio of maximum diameter to basal diameter and ratio of maximum diameter to height; tumor location, shape, internal echogenicity intensity, echogenicity uniformity, degree of sound attenuation, invasion of iris, anterior displacement of the iris, lens subluxation were observed. The measurement parameters and observation indexes of the two groups were compared by independent sample n t-test and n χn 2 test. Receiver operating characteristic (ROC) curve was drawn, area under the ROC curve (AUC) was determined, and parameter indicators with differential diagnosis value were screened.n Results:The maximum diameter, height, maximum basal diameter, ratio of the maximum diameter to the maximum basal diameter, and the ratio of the maximum diameter to the height of the tumors in the ANPCE group and the control group were 5.64±0.98 mm, 4.24±0.59 mm, 3.66±0.71 mm, 1.58±0.34, 1.34±0.19 and 7.82±2.03 mm, 4.47±2.44 mm, 7.02±1.96 mm, 1.13±0.16, 2.09±1.06. The maximum diameter, the maximum basal diameter, and the ratio of the maximum diameter to the height of the tumor in the ANPCE group were all smaller than those of the control group, and the ratio of the maximum diameter to the maximum basal diameter was greater than that of the control group, and the differences were statistically significant (n t=-4.159,-6.808, -2.924, 6.257; n P<0.05). The tumors in the ANPCE group were mainly spherical (87.1%, 27/31), with no significant acoustic attenuation (77.4%, 24/31), less invading the root iris (77.4%, 24/31), and the tumors were mostly located in the ciliary body coronal (74.2%, 23/31); tumors in the control group were mainly hemispherical (47.1%, 8/17) or spherical (47.1%, 8/17), with significant sound attenuation (76.5%, 13/17), most of the tumors invaded the iris (70.6%, 12/17), and the tumors were mostly located from the pars plana to the coronal (76.5%, 13/17). There were statistically significant differences in the position, shape, sound attenuation degree, and whether it invaded the iris between the two groups of eyes (n χn 2=15.132, 19.767, 13.118, 10.581; n P<0.05). The results of ROC curve analysis showed that the ratio of the largest diameter to the largest base diameter, the degree of sound attenuation and the AUC of whether the iris was violated were higher, which were 0.881, 0.769, and 0.740, respectively.n Conclusions:Ultrasound biomicroscopy is helpful in the diagnosis and differential diagnosis of ANPCE and ciliary body melanoma. The ratio of maximum diameter to maximum basal diameter, the degree of sound attenuation and whether it invades the root iris are important parameters to distinguish the two tumors.