浆细胞样树突状细胞(pDC)以快速分泌Ⅰ型IFN、抑制病毒及细菌等病原入侵的固有免疫应答著称。同时,pDC作为一种专职抗原提呈细胞,能呈递抗原,参与适应性免疫应答。近年来越来越多的研究证明,其分布于实体肿瘤组织内,呈递肿瘤抗原,参与免疫调节,导致肿瘤免疫逃逸。 Plasmacytoid dendritic cells (pDCs) are known for their ability to rapidly secrete type I IFN and inhibit innate immune responses such as viral and bacterial pathogen invasion. At the same time, pDC as a full-time antigen presenting cells, can present antigens, involved in adaptive immune response. In recent years, more and more studies have shown that it is distributed in solid tumor tissues and presented with tumor antigens, which are involved in immune regulation, resulting in tumor immune escape.