The acceleration autopilot design for skid-to-turn(STT) missile faces a great challenge owing to coupling effect among planes, variation of missile velocity and its parameters, inexistence of a complete state vector, and nonlinear aerodynamics. Moreover, the autopilot should be designed for the entire flight envelope where fast variations exist. In this paper, a design of integrated roll-pitch-yaw autopilot based on global fast terminal sliding mode control(GFTSMC) with a partial state nonlinear observer(PSNLO) for STT nonlinear time-varying missile model, is employed to address these issues. GFTSMC with a novel sliding surface is proposed to nullify the integral error and the singularity problem without application of the sign function. The proposed autopilot consisting of two-loop structure, controls STT maneuver and stabilizes the rolling with a PSNLO in order to estimate the immeasurable states as an output while its inputs are missile measurable states and control signals. The missile model considers the velocity variation, gravity effect and parameters’ variation. Furthermore, the environmental conditions’ dynamics are modeled. PSNLO stability and the closed loop system stability are studied. Finally, numerical simulation is established to evaluate the proposed autopilot performance and to compare it with existing approaches in the literature. The acceleration autopilot design for skid-to-turn (STT) missile faces a great challenge due to coupling effect among planes, variation of missile velocity and its parameters, inexistence of a complete state vector, and nonlinear aerodynamics. Moreover, the autopilot should be designed for the entire flight envelope where fast variations exist. In this paper, a design of integrated roll-pitch-yaw autopilot based on global fast terminal sliding mode control (GFTSMC) with a partial state nonlinear observer (PSNLO) for STT nonlinear time- varying missile model, is employed to address these issues. GFTSMC with a novel sliding surface is proposed to nullify the integral error and the singularity problem without application of the sign function. The proposed autopilot consisting of two-loop structure, controls STT maneuver and stabilizes the rolling with a PSNLO in order to estimate the immeasurable states as an output while its inputs are missile measurable states and control signals. The mis silencing model considers the velocity variation, gravity effect and parameters ’variation. Furthermore, the environmental conditions’ dynamics are modeled. PSNLO stability and closed loop system stability are studied. Finally, numerical simulation is established to evaluate the proposed autopilot performance and to compare it with existing approaches in the literature.