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目的探讨妇女人乳头状瘤病毒(HPV)及其他常见病原微生物感染现状。方法收集2009年1月~2011年12月在鄂州市中心医院妇科门诊就诊的2 021例妇女的宫颈和阴道拭子标本,PCR检查HPV DNA及其基因分型,同时检测病原体感染情况。结果 2 021例病例HPV阳性625例,阳性率为30.93%。在625例HPV阳性病例中,除52例为混合基因型,其余573例共检测出35种HPV的不同亚型,检出率较高的亚型分别是HPV16(14.83%)、HPV58(9.08%)、HPV53(7.50%)、HPV42(6.28%)、HPV31和HPV6(各5.41%);HPV高危型和可能高危型占52.53%,HPV低危型占22.86%,HPV未知危险型占24.61%。在HPV阳性625例妇女中,感染沙眼衣原体占12.80%,解脲支原体占33.92%,无乳链球菌占8.96%,阴道毛滴虫占1.12%,细菌性阴道病占9.44%,假丝酵母菌占12.64%。结论鄂州地区妇女高危型HPV感染率较高,早期筛查、控制HPV感染是降低宫颈癌发病率的有效途径。
Objective To investigate the status of women’s human papilloma virus (HPV) and other common pathogenic microorganisms. Methods Cervical and vaginal swab samples from 2 021 women who visited the gynecology clinic of Central Hospital of Ezhou from January 2009 to December 2011 were collected. HPV DNA and its genotypes were detected by PCR. Pathogen infection was also detected. Results There were 625 HPV positive cases in 2 021 cases, the positive rate was 30.93%. Among the 625 HPV-positive cases, the other 573 cases detected 35 subtypes of HPV with subtypes of HPV16 (14.83%), HPV58 (9.08% ), HPV53 (7.50%), HPV42 (6.28%), HPV31 and HPV6 (5.41% each). High-risk HPV types and high-risk HPV types accounted for 52.53%, HPV low-risk types accounted for 22.86%, and HPV unknowns accounted for 24.61%. In HPV-positive 625 women, Chlamydia trachomatis infection accounted for 12.80%, Ureaplasma urealyticum accounted for 33.92%, Streptococcus agalactiae accounted for 8.96%, Trichomonas vaginalis accounted for 1.12%, bacterial vaginosis accounted for 9.44%, Candida Accounting for 12.64%. Conclusion The prevalence of high-risk HPV infection in women in Ezhou Prefecture is high. Early screening and HPV infection control are effective ways to reduce the incidence of cervical cancer.