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目的:探讨肿瘤抑制基因Pten/MMAC1/Tep1在多形性胶质母细胞瘤中的作用。方法:用免疫组化ABC法检测20例多形性胶质母细胞瘤中Pten/MMAC1/Tep1基因的表达。结果:60%(12/20)病例该基因表达丢失;40%(8/20)表达低下;无一例表达正常。结论:Pten/MMAC1/Tep1表达异常可能与多形性胶质母细胞瘤的发生有关
Objective: To investigate the role of tumor suppressor gene Pten/MMAC1/Tep1 in glioblastoma multiforme. Methods: The expression of Pten/MMAC1/Tep1 gene in 20 cases of glioblastoma multiforme was detected by immunohistochemical ABC method. Results: The gene expression was lost in 60% (12/20) cases; 40% (8/20) expression was low; none was normal. Conclusion: The abnormal expression of Pten/MMAC1/Tep1 may be related to the occurrence of glioblastoma multiforme