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作者曾经报道P物质和eledoisin的六肽类似物(Eledoisin-hexapeptide analogue,简称EH)可促进大鼠学习和记忆过程的巩固,并将二者对正常大鼠条件反射学习的作用进行了比较。鉴于这两种肽对正常大鼠的促进作用并不十分显著,作者研究了EH对神经性高血压大鼠的学习和记忆过程的影响。实验用5～6个月龄的雄性Wistar大鼠48只,预先利用慢性减低运动机能产生的紧张状态(Chronichypokinesia stress)诱发大鼠患神经性高血压。经过10周,大鼠平均血压由120mm汞柱上升到150mm汞柱。这种高血压大鼠还表现出学习记忆的缺陷以及行为型式的损伤,如学习曲线降低(学习开始迟缓,在特定
The authors have reported that substance E and Eledoisin hexadeptide analog (Eledoisin-hexapeptide analogue, EH for short) can promote the learning and memory of rats to consolidate, and the two were compared to the normal rat reflex learning. In view of these two peptides on the promotion of normal rats is not very significant, the authors studied the EH in rats with learning and memory of the impact of learning and memory. Forty-eight male Wistar rats aged 5 to 6 months were used to induce neuropathic hypertension in rats preliminarily using chronic hypokinesis-induced stress (Chronichypokinesia stress). After 10 weeks, the mean blood pressure in rats rose from 120 mm Hg to 150 mm Hg. This hypertensive rat also exhibits learning and memory deficits as well as behavioral pattern impairments such as reduced learning curve (learning starts slowly,