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目的 :探讨小儿良、恶性实体瘤可溶性白细胞介素 2受体 (s IL- 2 R)的表达差异及术后变化规律。方法 :采用EL ISA双抗体夹心法 ,对 30例恶性实体瘤、 15例良性实体瘤和 15例健康儿童进行了 s IL- 2 R术前和术后 2、 3、 7日动态监测。结果 :血清 s IL- 2 R水平在恶性组 (988.37u/ml)显著高于良性组 (5 0 6 .40 u/ml) ,无论良性还是恶性实体瘤患儿均显著高于对照 (342 .93u/ml)。术后一周观察显示 ,恶性组 s IL- 2 R呈上升趋势 ,而良性组则呈下降之态。结论 :实体瘤患儿 s IL-2 R的定量监测 ,既有助于观察病情和预后判断 ,也可作为肿瘤性质判断的依据之一。
Objective: To investigate the difference of sIL-2R expression in benign and malignant solid tumors of children and the change rules after operation. Methods: Thirty patients with malignant solid tumors, 15 benign solid tumors and 15 healthy children were enrolled in the study. IL-2 R preoperative and postoperative 2, 3 and 7 days were monitored dynamically by ELISA. Results: Serum IL-2R levels were significantly higher in the malignant group (988.37u / ml) than in the benign group (506.0uU / ml), both in benign and malignant solid tumors (342%). 93u / ml). A week after surgery showed that sIL-2R in malignant group showed an upward trend, while benign group showed a decline. Conclusion: The quantitative monitoring of IL-2R in children with solid tumors not only helps to observe the disease and prognosis, but also serves as a basis for judging the nature of the tumor.