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为了解围生期窒息新生儿血清 IL- 6水平的动态变化 ,采用双抗体夹心 EL ISA方法 ,检测 41例围生期窒息新生儿及 11例正常新生儿生后 0、 3、 7d血清 IL- 6的水平。结果 ,41例围生期窒息新生儿中 2 6例合并缺氧缺血性脑病 ,其中轻度 12例 ,中度 8例 ,重度 6例。对照组血清 IL- 6的水平生后 1w内无明显变化 ,缺氧缺血性脑病(HIE)组血清 IL- 6水平呈先升后降的趋势 :生后第 3天达高峰 ,第 7天下降 ,较 0 d水平低 ,随着 HIE程度的加重 ,IL- 6水平呈上升趋势。IL- 6参与 HIE的发病过程 ,血清 IL- 6水平与脑损伤的程度及预后密切相关。
In order to understand the dynamic changes of serum IL-6 levels in neonates with perinatal asphyxia, the serum levels of IL-6 in 41 neonates with perinatal asphyxia and 11 normal neonates at 0, 3 and 7 days after birth were measured by ELISA. s level. Results: Twenty-six of 41 neonates with perinatal asphyxia had hypoxic-ischemic encephalopathy, of which 12 were mild, 8 were moderate, and 6 were severe. The level of IL-6 in control group within 1w after birth, no significant changes in serum levels of IL-6 in hypoxic-ischemic encephalopathy (HIE) showed a trend of rising first and then decreasing: the third day after birth reached the peak, the first 7 days Decreased, compared with 0 d low level, with the degree of HIE increased, IL-6 levels are on the rise. IL-6 is involved in the pathogenesis of HIE. Serum IL-6 level is closely related to the degree and prognosis of brain injury.