研究表明转化生长因子 β(TGF β)是一基因家族编码产物 ,为多潜能生长因子 ,参与血管平滑肌细胞 (VSMC)增殖、细胞外基质 (ECM)沉积和血管重塑 ,并影响内皮素 (ET 1)合成和肾素 -血管紧张素系统 (RAS)相互调节。因此 ,与高血压及其血管并发症关系密切。新近还发现TGF β1的基因多态性与原发性高血压 (EH)发病有关 ,而这一基因家族的其它成员与高血压的关系也渐受关注。 Studies have shown that transforming growth factor β (TGFβ) is a gene family encoded product that is a pluripotent growth factor involved in proliferation of vascular smooth muscle cells (VSMCs), extracellular matrix (ECM) deposition and vascular remodeling and affects endothelin (ET 1) The synthesis and renin-angiotensin system (RAS) regulate each other. Therefore, with high blood pressure and vascular complications are closely related. Recently, TGFβ1 gene polymorphism has also been found to be associated with the pathogenesis of essential hypertension (EH), and other members of this gene family have also drawn increasing attention.