用动态透析系统和分光光度测定法考察了肝靶向制剂──米托蒽醌聚氰基丙烯酸正丁酯毫微球冻干注射剂的体外释药规律。结果表明该制剂在体外释药符合双指数双相动力学规律。释药过程前相为快速释药相，４小时可释出４０％以上药物，ｔ＿（１／２）α为１．４０小时；后相为缓释相，ｔ＿（１／２）β为１６９．０２小时。该靶向制剂释药规律符合常规用药原则，提示可用于临床。 The in vitro release of mitoxantrone-polybutylcyanoacrylate n-butyl nephelomere injection in vitro was investigated using a dynamic dialysis system and spectrophotometry. The results show that the formulation in vitro release in line with the double exponential biphasic kinetics. The phase of drug release was immediate release phase in 4 hours, and the t_ (1/2) α was 1.40 hours in 4 hours. The latter phase was sustained release phase, and the value of t_ (1/2) β was 169 .02 hours. The release rate of the targeted preparation conformed to the principle of regular medication, which indicated that it could be used clinically.