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用透射电镜观察脑梗塞边缘星形细胞超微结构动态改变,大脑中动脉闭塞(MCAO)后2小时星形细胞间隙首先出现水肿。6～12小时微血管周星形细胞突起肿大。1天,微血管周间隙增宽,星形细胞突起肿胀愈来愈严重。3天,星形细胞内细胞器成碎片。5～7天,星形细胞线粒体渐增多、肿大。在MCAO后肿大的星形细胞多出现在变形的微血管旁,有单核细胞浸润的脑组织和坏死的神经细胞区,星形细胞中溶酶体增多,其相邻的神经细胞溶酶体也多。说明星形细胞在缺血性脑水肿中起着一种保护作用,其增生肿大,接近变形的微血管和频临坏死的神经细胞,目的是保护他们不再受损害。
Transmission electron microscopy was used to observe the dynamic changes of the ultrastructure of astrocytes at the border of cerebral infarction. Edema appeared first in the interstitial space of astrocytes 2 hours after middle cerebral artery occlusion (MCAO). 6 ~ 12 hours microvascular astrocytoma swelling. One day, the perivascular space widened and the swelling of astrocytes became more and more serious. 3 days, astrocytes organelles into pieces. 5 to 7 days, astrocytes mitochondrial gradually increased, enlarged. Astrocytes enlarged after MCAO appear in the vicinity of the deformed microvessels, monocytes infiltrating brain tissue and necrotic neuronal cells, astrocytes increased lysosomes, adjacent neurons lysosomes Also more. Description Astrocytes play a protective role in ischemic brain edema, with hyperplasia, near-deformative microvasculature, and the presence of necrotic neurons in order to protect them from further damage.