论文部分内容阅读
通过分析维吾尔族长寿家系与非长寿家系血浆纤维蛋白原年龄变化特点，以及两种家系亲缘关系对子代血浆纤维蛋白原水平的影响，探讨血浆纤维蛋白原与人类寿命的家族聚集性的关系。方法：采用凝血酶钩针法检测了７个维吾尔族长寿家系和９个非长寿家系１３７名成员及两种家系成员中的１６名配偶的血浆纤维蛋白原水平。结果：长寿家系中不同年龄组间血浆纤维蛋白原水平维持相对稳定，非长寿家系中血浆纤维蛋白原水平表现出明显随年龄升高趋势。亲代与子代血浆纤维蛋白原水平显著相关。提示：血浆纤维蛋白原水平可能主要受遗传基因控制，并与人类寿命的家族聚集现象有关
By analyzing the characteristics of plasma fibrinogen age in Uighur longevous and non-longevous families, and the influence of the kinship between the two families on plasma fibrinogen levels in offspring, the relationship between plasma fibrinogen and the familial aggregation of human life span was explored. METHODS: Plasma fibrinogen levels were measured in 137 Uyghur longevous and nine non-longevous pedigrees and 16 of the two family members using the thrombin crochet method. Results: Plasma fibrinogen levels remained relatively stable in different age groups in longevity families, and plasma fibrinogen levels in non-longevous families showed a clear trend with age. Parental and offspring plasma fibrinogen levels were significantly correlated. Tip: Plasma fibrinogen levels may be mainly controlled by genes and are associated with familial aggregation of human lifespan