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目的:观察胃肠安丸对功能性消化不良(FD)肝郁脾虚模型大鼠胃排空的影响。方法:将50只SD大鼠随机分为正常对照组,模型组,胃肠安丸高、低剂量组和吗丁啉组,每组10只。除正常对照组外,其余各组均采用“夹尾激怒加不规律饮食法”制作FD肝郁脾虚型大鼠模型。造模成功后,胃肠安丸高、低剂量组分别灌胃胃肠安丸混悬液50.4mg/kg·d、25.2mg/kg·d,吗丁啉组灌服吗丁啉混悬液2.7mg/kg·d,正常对照组与模型组灌服等体积生理盐水,每天1次,连续给药7d。检测胃内残留率,判定各组大鼠的胃排空力水平。结果:与正常对照组相比,模型组胃内残留率增高,差异有统计学意义(P<0.05);与模型组相比,胃肠安丸高、低剂量组及吗丁啉组大鼠胃内残留率均降低,差异有统计学意义(P<0.05)。结论:胃肠安丸可以有效降低FD肝郁脾虚模型大鼠的胃内残留率,促进胃排空。
Objective: To observe the effects of Weishangan pill on gastric emptying in rats with functional dyspepsia (FD) and liver depression and spleen deficiency syndrome. Methods: Fifty Sprague-Dawley rats were randomly divided into normal control group, model group, Weisuanan high-dose group, low-dose group and domperidone group, with 10 rats in each group. In addition to the normal control group, the remaining groups were used “folder anger irritation plus irregular diet ” to make FD rat model of liver spleen deficiency. After the model was established successfully, the rats in the high and low doses of Weisuanan pill were administered with 50.4mg / kg · d and 25.2mg / kg · d, respectively. The mice in the domperidone group were dosed with the ambroxol suspension 2.7mg / kg · d, normal control group and model group were fed with equal volume of normal saline once a day for 7 days. The gastric residual rate was detected to determine the gastric emptying power of rats in each group. Results: Compared with the normal control group, the gastric residual rate in the model group was significantly increased (P <0.05). Compared with the model group, Within the residual rate were reduced, the difference was statistically significant (P <0.05). Conclusion: Weizhang’an Pill can effectively reduce gastric residual rate in FD model rats with liver-qi stagnation syndrome and promote gastric emptying.