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制备鸡血藤酚微乳和微乳凝胶剂,并对其含量、理化性质和体外透皮特性进行考察。方法:以IPM为油相,卵磷脂/APG为表面活性剂,1,2-丙二醇为助表面活性剂,在室温下采用磁力搅拌法滴加水到油相中,制备鸡血藤酚微乳。采用HPLC法测定鸡血藤酚微乳中鸡血藤酚的含量。采用透射电镜和激光粒径测定仪分别测定微乳的形态和粒径。以卡波姆940为基质,制备鸡血藤酚微乳凝胶。采用Franz扩散池对微乳、微乳凝胶的体外透皮特性进行了考察。结果:制备的鸡血藤酚微乳为O/W型微乳,外观圆整、均匀,粒径为32nm,含量稳定。鸡血藤酚饱和水溶液、微乳、微乳凝胶的稳态渗透速率分别为-2-1-2-1-2-1-2-247.846μgcmh、103.760μgcmh和70.401μgcmh,12h的累积渗透量分别为657.179μgcm、1266.484μgcm和-2881.217μgcm。结论:鸡血藤酚微乳、微乳凝胶的12h累积渗透量和渗透速率均优于鸡血藤酚饱和水溶液,可为鸡血藤酚经皮给药提供一种新的剂型。
Preparation of hemlock phenol microemulsion and microemulsion gel, and its content, physical and chemical properties and in vitro transdermal properties were investigated. Methods: IPM as oil phase, lecithin / APG as surfactant and 1,2-propanediol as co-surfactant were added dropwise to the oil phase by magnetic stirring at room temperature to prepare spironolactone microemulsion. Determination of Rothropanol in Mildew Test Microemulsion by. Transmission electron microscopy and laser particle size analyzer were used to determine the microemulsion morphology and particle size. Carbopol 940 was used as a matrix to prepare the spartelulose microemulsion. The Franz diffusion cell was used to investigate the in vitro transdermal properties of microemulsions and microemulsions. Results: The micro-emulsion of hemlock phenol was O / W microemulsion. The appearance was round and uniform, the particle size was 32nm and the content was stable. The steady-state permeation rates of splenol-saturated aqueous solution, microemulsion and microemulsion gel were -2-1-2-1-2-1-2-247.846μgcmh, 103.760μgcmh and 70.401μgcmh respectively, and the cumulative permeation amount of 12h 657.179 μgcm, 1266.484 μgcm and -2881.217 μgcm, respectively. CONCLUSION: The cumulative permeation rate and permeation rate of hemlock phenol microemulsion and microemulsion gel are better than that of splenol saturated solution, which can provide a new dosage form for transdermal administration of spironolactone.