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Prolonged overproduction of growth hormone,like insulin-like growth factor-1 hypersecretion leads to acromegaly in adults.This is associated with several co-morbidities and increased mortality.Despite typical clinical features and modern diagnostic tools,it often takes years to diagnose from the onset of the disease.The aims of the treatment are to reduce or control tumour growth,inhibit growth hormone hypersecretion,normalize insulin-like growth factor-1 levels,treat co-morbidities and,therefore,reduce mortality.There are three approaches for therapy:surgery,medical management(dopamine agonists,somatostatin analogues and growth hormone receptor
Prolonged overproduction of growth hormone, like insulin-like growth factor-1 hypersecretion leads to acromegaly in adults. This is associated with several co-morbidities and increased mortality. Despite typical clinical features and modern diagnostic tools, it often takes years to diagnose from the onset of the disease. The aims of the treatment are to reduce or control tumor growth, inhibit growth hormone hypersecretion, normalize insulin-like growth factor-1 levels, treat co-morbidities and, therefore, reduce mortality. There are three approaches for therapy : surgery, medical management (dopamine agonists, somatostatin analogues and growth hormone receptor