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本实验采用听生理方法和耳蜗组织化学方法观察了爆震对豚鼠听力和耳蜗琥珀酸脱氢酶、苹果酸脱氢酶的影响。结果表明:(1)爆震使豚鼠耳蜗内琥珀酸脱氢酶、苹果酸脱氢酶活性下新;(2)爆震引起的听力学改变,与耳蜗内SDH、MDH活性呈负相关。如果是这样,那末,在考虑声损伤的防治时,就可以从维持上述两种酶的活性来看手;(3)若听力损失限制在40dB以内,因酶活性下降和听力损失是可逆的,故可避免战位人员的永久性听力损失;听力损失超过40dB,若无有效措施使酶的活性逆转,则会遗留永久性听力损失,治疗效果可能欠佳。
In this study, the effects of detonation on auditory hearing and cochlea succinate dehydrogenase and malate dehydrogenase in guinea pigs were observed by the method of auditory physiology and cochlear histochemistry. The results showed that: (1) detonation induced the activity of succinate dehydrogenase and malate dehydrogenase in the cochlea of guinea pig; (2) The detonation induced audiological changes were negatively correlated with the activity of SDH and MDH in the cochlea. If so, then, in considering the prevention and treatment of acoustic damage, we can look at the hand to maintain the activity of the two enzymes; (3) if the hearing loss is limited to 40dB or less, due to decreased enzyme activity and hearing loss is reversible, Therefore, permanent hearing loss can be avoided for combatant personnel. Hearing loss exceeds 40 dB. If there is no effective measure to reverse the enzyme activity, permanent hearing loss will be left and the treatment effect may be poor.