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目的:探讨MMP-9、TI MP-1水平与脑梗死TOAST分型及病情的关系。方法:急性脑梗死患者60例(脑梗死组),记录患者入院时NI HSS评分,分为心源性脑栓塞组、大动脉粥样硬化性卒中组和小动脉卒中组共3个亚组各20例,测定发病24 h内、第5天和第10天血清MMP-9、TI MP-1水平,并选择同期20例健康体检者作为对照组。结果:发病24 h内,脑梗死组血清MMP-9及TI MP-1水平均升高,其中心源性脑栓塞组和大动脉粥样硬化性卒中组水平均高于小动脉卒中组(P<0.05);心源性脑栓塞组和大动脉粥样硬化性卒中组水平持续至第5天仍未下降,而小动脉卒中组已降至正常水平;第10天各组均降至正常水平。发病24 h内血清MMP-9与TI MP-1水平及NI HSS评分均呈正相关性。结论:脑梗死后血清MMP-9、TI MP-1水平升高,二者变化趋势相似。MMP-9一定程度上可反映病情轻重程度。
Objective: To investigate the relationship between the levels of MMP-9, TI-MP-1 and TOAST classification of cerebral infarction. Methods: Sixty patients with acute cerebral infarction (cerebral infarction group) were enrolled in this study. NIHSS scores were recorded on admission and divided into three groups of 20: cardiogenic cerebral embolism group, aortic atherosclerotic stroke group and arteriole stroke group. For example, serum MMP-9 and TI-MP-1 levels were measured within 24 hours, 5 days and 10 days, and 20 healthy subjects were selected as the control group. Results: Serum levels of MMP-9 and TI-MP-1 in cerebral infarction group increased within 24 hours after onset, and the levels in central-derived cerebral embolism group and aortic atherosclerosis group were higher than those in arteriolar small stroke group (P < 0.05). Cardiac brain embolism group and aortic atherosclerosis group did not decline until day 5, while the arteriolar stroke group had dropped to normal level; on the 10th day, the levels in all groups dropped to normal levels. Serum MMP-9 was positively correlated with TI MP-1 level and NIHSS score within 24 hours of onset. Conclusion: The levels of serum MMP-9 and TI-MP-1 are increased after cerebral infarction, and the trend of the two is similar. MMP-9 to a certain extent, reflect the severity of the disease.