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目的探讨胰岛素抵抗与冠心病的相关性。方法选取该院收治的72例急性冠状动脉综合征患者(ACS组)和60例稳定性心绞痛患者(SA组)作为研究对象,另选取同期在该院进行健康体检的50例健康人作为对照组,采集3组研究对象的空腹及餐后2 h静脉血,进行IS(血浆胰岛素)、血糖(BG)和CP(C肽)检测,并计算IS/BG、CP/BG值,比较3组研究对象的检测结果。结果 ACS组和SA组的餐后2 h及空腹IS值均显著高于对照组(P<0.05);ACS餐后2 h和空腹CP值、CP/BG值均显著高于对照组(P<0.05);ACS组和SA组的空腹IS/BG值均显著高于对照组(P<0.05),差异均具有统计学意义。ACS组餐后2 h及空腹状况下的CP、IS、CP/BG、IS/BG值,均显著高于SA组(P<0.05),差异均具有统计学意义。结论稳定性心绞痛和急性冠脉综合征患者普遍存在胰岛素抵抗,并且胰岛素抵抗会随着病情的加重而加重。
Objective To investigate the relationship between insulin resistance and coronary heart disease. Methods A total of 72 patients with acute coronary syndrome (ACS group) and 60 patients with stable angina pectoris (SA group) were enrolled in this study. Fifty healthy subjects in the same hospital during the same period were selected as the control group The fasting and postprandial 2-h venous blood samples of three groups were collected to detect IS (plasma insulin), blood glucose (BG) and CP (C peptide), and the IS / BG and CP / Object test results. Results After 2 h of fasting and fasting IS values in ACS group and SA group were significantly higher than those in control group (P <0.05); ACS 2 h after meal and fasting CP value and CP / BG value were significantly higher than those in control group (P < 0.05). The fasting IS / BG values in ACS group and SA group were significantly higher than those in control group (P <0.05), the differences were statistically significant. The CP, IS, CP / BG, IS / BG values at 2 h postprandial and fasting in ACS group were significantly higher than those in SA group (P <0.05). The differences were statistically significant. Conclusions Insulin resistance is prevalent in patients with stable angina and acute coronary syndromes, and insulin resistance worsens as the condition progresses.