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本实验采用自行设计并成功建立的全脑缺氧动物模型,着重对全脑缺氧发展的不同阶段包括脑再供氧条件下神经组织病理改变特征与同期动物脑匀浆、血中LPO、Fe、SOD活性变化加以综合研究。结果发现完全性脑缺氧及脑再供氧的不同阶段均有神经细胞不同范围不同程度的局部缺血性改变,且再供氧阶段神经组织损害更为严重。脑缺氧发展金过程LPO、Fe、SOD活性变化有自身内在规律,又与神经病理改变有着内在联系。
In this study, an animal model of whole brain hypoxia, which was designed and established by ourselves, was emphatically focused on the different stages of global cerebral hypoxia, including the pathological changes of neural tissue under brain reoxygenation conditions, brain homogenate, LPO, Fe , SOD activity to be comprehensive study. The results showed that in different stages of complete cerebral hypoxia and brain reoxygenation, there are varying degrees of ischemic changes in different areas of nerve cells, and nerve tissue damage is more serious in reoxygenation stage. The changes of LPO, Fe and SOD activity during brain hypoxic development have their own inherent rules, and are also intrinsically linked with neuropathological changes.