论文部分内容阅读
目的评估0.1 g·L~(-1)阿托品滴眼液对瞳孔直径和调节的影响,以及不同溶剂对阿托品药理作用的影响。方法本研究对23名(46眼)受试者采用队列研究,根据0.1g·L~(-1)阿托品配制溶剂不同,将受试者随机分为生理盐水组和玻璃酸钠组,每组各23眼。试验前对所有受试者进行电脑验光、调节幅度、近视力、瞳孔直径以及瞳孔对光反射的测量,阿托品点眼后不同时间依次进行瞳孔直径的测量,当瞳孔散至最大时,我们将再次进行电脑验光、剩余调节力、近视力、瞳孔直径及瞳孔对光反射检查,并进行问卷调查。结果生理盐水组用药前瞳孔直径为(5.15±0.22)mm,调节幅度为(10.09±0.35)D,瞳孔充分散大后,瞳孔直径为(6.52±0.21)mm,剩余调节力为(8.79±0.36)D,差异均具有统计学意义(均为P<0.001);玻璃酸钠组用药前瞳孔直径为(5.04±0.22)mm,调节幅度为(10.17±0.46)D,瞳孔充分散大后,瞳孔直径为(6.86±0.21)mm,剩余调节力为(8.83±0.39)D,差异均具有统计学意义(均为P<0.001)。两组0.1 g·L~(-1)阿托品滴眼液点眼后,近视力均轻度下降,但差异均无统计学意义(均为P>0.05)。问卷调查结果显示,0.1 g·L~(-1)阿托品点眼后会出现轻微不适,但不影响近距离工作。结论 0.1 g·L~(-1)阿托品会造成瞳孔散大,但保留了功能性调节,不会引起明显的不适症状,对近距离工作和生活学习无明显影响;溶剂的类型不会影响阿托品的药理作用。
Objective To evaluate the effects of 0.1 g · L -1 atropine eye drops on pupil diameter and regulation, and the effects of different solvents on the pharmacological effects of atropine. Methods In this study, 23 subjects (46 eyes) were enrolled in a cohort study. Subjects were randomly divided into normal saline group and sodium hyaluronate group according to 0.1g · L -1 atropine. Each 23 eyes. All subjects underwent computer optometry, adjustment of amplitude, near-vision, pupil diameter, and pupil light reflexes prior to testing. Atropine was measured pupil diameter at different times after eye contact, and when the pupil was maximal we would proceed again Computer optometry, residual accommodative power, near vision, pupil diameter and pupil light reflex examination, and questionnaires. Results The diameter of pupil was (5.15 ± 0.22) mm and the amplitude of adjustment was (10.05 ± 0.22) mm. The diameter of pupil was (6.52 ± 0.21) mm and the residual accommodative power was (8.79 ± 0.36) mm ), The differences were statistically significant (all P <0.001); before treatment, the pupil diameter of the sodium hyaluronate group was (5.04 ± 0.22) mm and the amplitude of adjustment was (10.17 ± 0.46) D. After the pupil was fully enlarged, The diameter was (6.86 ± 0.21) mm and the remaining adjustment force was (8.83 ± 0.39) D, the difference was statistically significant (both P <0.001). After two groups of 0.1 g · L -1 atropine eye drops, the near vision decreased slightly, but the differences were not statistically significant (both P> 0.05). The results of the questionnaire survey showed that 0.1 g · L -1 atropine may appear mild discomfort after eye contact, but it will not affect close work. Conclusions Atropine 0.1 g · L -1 can cause mydriasis, but retains functional regulation without obvious discomfort and has no obvious effect on close working and living study. The type of solvent does not affect atropine Pharmacological effects.