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为探讨成纤维细胞生长因子（ｆｉｂｒｏｂｌａｓｔｇｒｏｗｔｈｆａｃｔｏｒ，ＦＧＦ）在鼻息肉组织中的表达及其与鼻息肉上皮细胞增殖之间的关系，将２６例鼻息肉标本及１４例下鼻甲标本行ＦＧＦ和增殖细胞抗原（ｐｒｏ－ｌｉｆｅｒａｔｉｎｇｃｅｌｎｕｃｌｅａｒａｎｔｉｇｅｎ，ＰＣＮＡ）的免疫组化染色，光镜观察，结果发现ＰＣＮＡ在鼻息肉组的阳性率（７８．６％）显著高于下鼻甲组（０．０％），ＦＧＦ在鼻息肉组的上皮及腺体的阳性表达率明显高于下鼻甲组（Ｐ＜０．０１，Ｐ＜０．００１），且二者的表达具有显著正相关（Ｐ＜０．０１）。我们推测ＦＧＦ对鼻息肉上皮及腺体细胞的增殖具有促进作用并参与鼻息肉的形成。
To investigate the expression of fibroblast growth factor (FGF) in nasal polyps and its relationship with the proliferation of nasal polyps, 26 cases of nasal polyps and 14 cases of inferior turbinate were treated with FGF and proliferating cell antigen (PCNA) immunohistochemistry and light microscopy. The results showed that the positive rate of PCNA in nasal polyps (78.6%) was significantly higher than that in inferior turbinate (0.0%), and the positive rate of FGF in nasal polyps The positive expression rates of epithelium and gland in the group were significantly higher than those in the inferior turbinate group (P <0.01, P <0.001), and there was a significant positive correlation between them (P <0.01). We speculate that FGF can promote the proliferation of nasal polyp epithelial cells and glandular cells and participate in the formation of nasal polyps.