血管紧张素转换酶(ACE)是一种二肽羧基肽酶,主要分布在肺毛细血管内皮细胞管腔面,此酶使血管紧张素Ⅰ转换成血管紧张素Ⅱ,并使缓激肽灭活。最初在结节病患者中发现其活性增高,继之发现在其他疾病中也有增高,如高雪氏病、麻风、矽肺和石棉肺、甲状腺机能亢进和糖尿病性视网膜病。之后在急性肝炎和肝硬化患者中也发现ACE活性增高。但在较大范围肝脏疾 Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxypeptidase mainly distributed in the luminal surface of pulmonary capillary endothelial cells. This enzyme converts angiotensin I to angiotensin II and inactivates bradykinin . It was initially found to have increased activity in patients with sarcoidosis, followed by an increase in other diseases such as Gaucher’s disease, leprosy, silicosis and asbestosis, hyperthyroidism and diabetic retinopathy. Afterwards, ACE activity was also found to be elevated in patients with acute hepatitis and cirrhosis. But in a wide range of liver disease