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二甲胺四环素（Ｍｉｎｏｃｙｃｌｉｎｅ，ＭＩＮＯ）为四环素族抗生素中抗菌活性最强的一种，抗菌谱广，口服吸收良好。本研究用ＭＩＮＯ治疗１００例轻中度消化道、泌尿道、呼吸道感染及其他感染，其中５０例与强力霉素（Ｄｏｘｙｃｙｃｌｉｎｅ，ＤＯＸＹ）随机对照。剂量均为１００ｍｇ，１天２次，首剂加倍。结果示随机对照组ＭＩＮＯ和ＤＯＸＹ有效率分别为９６．７％和６８％（ｐ＜０．０５），有显著差异。细菌阴转率分别为９０．９％和７６．９％（ｐ＞０．０５）。ＭＩＮＯ治疗开放组感染５０例，有效率为９８％，细菌阴转率为８７．２％。ＭＩＮＯ组总副反应率为２５％，主要表现为头昏和恶心，未见肝肾功能损害。体外抗菌活性显示ＭＩＮＯ对金葡球菌有较强的抗菌活性，ＭＩＣ９０为２ｍｇ／Ｌ，但对革兰氏阴性杆菌抗菌活性较差。
Minocycline (Minocycline, MINO) tetracycline antibiotics in the antibacterial activity of the strongest, broad antibacterial spectrum, good oral absorption. In this study, 100 cases of mild to moderate digestive tract, urinary tract, respiratory tract infection and other infections were treated with MINO, of which 50 were randomized to doxycycline (DOXY). The dose was 100mg twice a day, the first dose doubled. The results showed that the randomized control group MINO and DOXY effective rates were 96.7% and 68% (p <0.05), a significant difference. Bacterial negative rates were 90.9% and 76.9%, respectively (p> 0.05). 50 cases of MINO open group infection, the effective rate was 98%, the bacterial negative conversion rate was 87.2%. MINO group total adverse reaction rate was 25%, mainly manifested as dizziness and nausea, no liver and kidney dysfunction. In vitro antibacterial activity showed that MINO had strong antibacterial activity against Staphylococcus aureus, MIC90 was 2mg / L, but antibacterial activity against Gram-negative bacilli was poor.