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目的探讨急性心肌梗死患者血浆P-选择素(P-selectin,Ps)的含量及其意义。方法 2009年12月2010年5月间采用酶联免疫吸附试验分别测定35例冠心病患者、30例急性心肌梗死患者急性期及恢复期两个时期血浆中Ps、血清心肌肌钙蛋白I(cTnI)和肌红蛋白(Myo)含量,与20例健康体检者作对照。结果急性心肌梗死急性期与恢复期比较,Ps、cTnI和Myo水平明显上升(P<0.05);急性心肌梗死急性期与冠心病组比较也差异统计学意义(P<0.05),均高于对照组(P<0.05)。急性心肌梗死恢复期与冠心病组比较差异无统计学意义(P>0.05)。结论 Ps、cTnI和Myo水平升高与急性心肌梗死的进展有关,可作为鉴别诊断急性心肌梗死的指标。
Objective To investigate the content and significance of plasma P-selectin (Ps) in patients with acute myocardial infarction. Methods Plasma levels of Ps, serum cardiac troponin I (cTnI) in 35 patients with coronary heart disease and 30 patients with acute myocardial infarction in acute phase and convalescent phase were measured by enzyme linked immunosorbent assay (ELISA) from December 2009 to May 2010. ) And myoglobin (Myo), compared with 20 healthy subjects. Results The levels of Ps, cTnI and Myo in acute and acute myocardial infarction group were significantly higher than those in convalescent group (P <0.05). There was also a significant difference between acute myocardial infarction and coronary heart disease group (P <0.05) Group (P <0.05). The recovery of acute myocardial infarction compared with coronary heart disease group was no significant difference (P> 0.05). Conclusions The elevated levels of Ps, cTnI and Myo are associated with the progression of acute myocardial infarction and may be used as an index to differentiate acute myocardial infarction.