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目的:探讨PCOS患者体重指数(BMI)与子宫内膜IRS-1、GLUT4等表达的相关性。方法:选取在本院就诊的PCOS患者60例,按BMI分为3组:<25kg/m~2组(A组,20例),25kg/m~2≤BMI≤30kg/m~2组(B组,25例),>30kg/m~2组(C组,15例)。选取20例输卵管性因素不孕患者为对照组。于卵泡期刮取内膜,免疫组化染色和Western blot法检测子宫内膜IRS-1、GLUT4表达。结果:BMI高值组的IRS-1、GLUT4表达明显低于BMI低值组。BMI水平与子宫内膜IRS-1、GLUT4呈负相关(P<0.05)。结论:升高的BMI可能是PCOS患者子宫内膜发生胰岛素抵抗的危险因素之一。
Objective: To investigate the correlation between the body mass index (BMI) and the expression of IRS-1 and GLUT4 in PCOS patients. Methods: Sixty PCOS patients in our hospital were selected and divided into three groups according to BMI: 25kg / m ~ 2 (group A, 20 cases), 25kg / m ~ 2≤BMI≤30kg / B group, 25 cases),> 30kg / m ~ 2 group (C group, 15 cases). Twenty cases of tubal infertility were selected as the control group. The endometrium was scored during follicular phase. The expression of IRS-1 and GLUT4 in endometrium was detected by immunohistochemistry and Western blot. Results: The expression of IRS-1 and GLUT4 in high BMI group was significantly lower than that in low BMI group. The level of BMI was negatively correlated with IRS-1 and GLUT4 in endometrium (P <0.05). Conclusions: Elevated BMI may be one of the risk factors of insulin resistance in endometrial PCOS.