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目的:对广东产毛鱼藤(Derris elliptica (Roxb.) Benth.)根的化学成分进行研究。方法:运用多种层析手段进行分离纯化, 通过波谱解析和理化鉴别进行结构鉴定。结果:分离鉴定了7个鱼藤酮类化合物, 分别为:7′-羟基-6a, 12a-脱氢鱼藤素(7′-hydroxy-6a, 12a-dehydrodeguelin, 1), 6-羟基-6a, 12a-脱氢鱼藤素(6-hydroxy-6a, 12a- dehydrodeguelin, 2), (6aR, 12aR, 4′R, 5′S)-4′, 5′-dihydro-4′, 5′-dihydroxytephrosin (3), 6′-羟基-6a, 12a-脱氢鱼藤酮(6′-hydroxy-6a, 12a-dehydrorotenone, 4), (-)-rotoic acid (5), (-)-deguoic acid(6), 12-deoxo-12α-acetoxyelliptone(7)。结论:化合物1为新化合物, 化合物2～ 6为首次从鱼藤属中分得, 化合物7为首次从毛鱼藤中分得。
Objective: To study the chemical constituents of the roots of Derris elliptica (Roxb.) Benth. Methods: Various chromatographic methods were used for isolation and purification, and their structures were identified by spectral analysis and physical and chemical identification. Results: Seven rotenone compounds were isolated and identified as 7’-hydroxy-6a, 12a-dehydrodeguelin (1), 6-hydroxy-6a, 12a - 6-hydroxy-6a, 12a-dehydrodeguelin, (6aR, 12aR, 4’R, 5’S) -4 ’, 5’-dihydro- 4’, 5’-dihydroxytephrosin 3), 6’-hydroxy-6a, 12a-dehydrototenone (4), (-) - rotoic acid 12-deoxo-12α-acetoxyelliptone (7). CONCLUSION: Compound 1 is a new compound. Compounds 2 ~ 6 are obtained from the genus Genus for the first time. Compound 7 is first isolated from the genus Mao.