近年来,性激素及其代谢产物在风湿病中的作用越来越引起人们的注意。临床及实验室研究已经证明,风湿病患者的各种病理状态,从轻微的皮肤及关节受累到严重的免疫机能损害都明显受到性激素的影响。在系统性红斑狼疮(SLE)、类风湿性关节炎(RA)及皮肌炎(DM)等疾病,女性的发病率明显高于男性,而在强直性脊柱炎、Reiter氏综合征,痛风等则主要为男性受累。许多临床观察发现,妊娠及口服雌激素类避孕药均可使SLE、RA及白塞氏综合征等患者的病情改善或恶化。这些与性激素水 In recent years, the role of sex hormones and their metabolites in rheumatism has drawn more and more attention. Clinical and laboratory studies have shown that the various pathological conditions of patients with rheumatism, from mild skin and joint involvement to severe immune dysfunction are significantly affected by sex hormones. In systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and dermatomyositis (DM) and other diseases, the incidence of women was significantly higher than men, and in ankylosing spondylitis, Reiter’s Syndrome, gout The main male involvement. Many clinical observations have found that pregnancy and oral estrogen contraceptives can ameliorate or worsen the condition of patients such as SLE, RA and Behcet’s syndrome. These and sex hormone water