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目的:研究T淋巴细胞是否参与了不稳定型心绞痛(UA)相关的炎症反应.方法:空腹采肘静脉血,采用流式细胞分析仪分析19 例UA、21 例稳定型心绞痛(SA)患者和16 例健康者循环T淋巴细胞亚群和T细胞激活标志物CD25和HLA－DR抗原的表达,双抗体夹心ELISA法测定血清可溶性白细胞介素－2 受体(SIL－2R).结果:UA患者HLA－DR阳性的淋巴细胞数量和SIL－2R水平显著高于SA患者和健康者.结论:UA患者循环T淋巴细胞被激活,免疫炎症反应参与了UA的发生.“,”Objective:To investigate whether circulating lymphocytes took part in the inflammatory reaction which related to unstable angina.Method:Nineteen patients with unstable angina,21 patients with unstable angina,and 16 healthy subjects were studied. The activating markers of T lymphocytes,CD 25 and HLA DR,were investigated by flow cytometric analysis. Soluble interleukin 2 receptor (sIL 2R) was measured in plasma by ELASA.Result:The results demonstrated that the number of HLA DR + lymphocytes and the level of sIL 2R in patients with unstable angina were higher (P< 0.01 ) than those in patients with stable angina and in control subjects.Conclusion:These results suggest that circulating T lymphocytes are activated in patients with unstable angina and immune system mediated inflammation may play an important role in the pathophysiology of unstable angina.