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本文最初发表于《Blood》杂志2015年第126卷,题录为:Wang Y,Huang W,Hu L,et al.Multicenter study of combination DEP regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis[J].Blood,2015,126:2186-2192。这是全球第一个关于难治性成人噬血细胞综合征(HLH)的前瞻性临床研究。研究结果显示DEP方案是一种有效的挽救治疗成人难治性HLH的手段,能够延长患者生存为寻找HLH原发病提供机会,可能成为诱导治疗向病因治疗过渡的桥梁。本文经通信作者的许可,再次通过佳文解读的方式阐明这一治疗方案,供各位赏析。
This article was originally published in Blood Volume 2015, Volume 126, titled Wang Y, Huang W, Hu L, et al. Multicenter study of combination DEP regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis [J]. Blood 2015, 126: 2186-2192. This is the world’s first prospective clinical study of refractory adult hemophagocytic syndrome (HLH). The results show that DEP is an effective rescue and treatment of refractory HLH in adults. It can prolong survival of patients and provide opportunities for finding the primary disease of HLH, which may become a bridge to induce the transition from treatment to cause treatment. This article with the permission of the author of the communication, once again through the interpretation of the text of the treatment of this treatment program for your appreciation.