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目的:观察三维适形放射治疗(3DCRT)联合热疗对宫颈癌的临床疗效,微波热疗次数与疗效关系及3DCRT联合热疗与放射并发症的关系。方法:53例患者中,采用3DCRT29例(3DCRT组),3DCRT联合热疗治疗24例(3DCRT联合热疗组)。治疗结束后,统计分析两组临床疗效及放射反应的差异,并分析微波热疗次数与疗效关系。结果:3DCRT组有效率为72.41%,3DCRT联合热疗组有效率为83.33%;微波热疗次数≥4次有效率为90.00%,<4次有效率为75.00%;放射并发症近期反应中,3DCRT组直肠反应的发生率为37.9%,3DCRT联合热疗组发生率为29.2%;3DCRT组膀胱反应发生率为17.2%,3DCRT联合热疗组发生率为12.5%;远期放射反应中,3DCRT组轻、中度放射性直肠炎发生率为13.8%,3DCRT联合热疗组发生率为8.3%;3DCRT组放射性膀胱炎发生率为10.3%,3DCRT联合热疗组发生率为8.3%。两组之间差异有显著性(P<0.05)。结论:3DCRT联合热疗能更有效地控制肿瘤的发展,更有效地控制放射并发症;微波治疗次数与疗效呈正相关。
Objective: To observe the clinical effect of 3DCRT combined with hyperthermia on cervical cancer, the relationship between the frequency of microwave hyperthermia and curative effect and the relationship between 3DCRT combined hyperthermia and radiation complications. Methods: Among 53 patients, 3DCRT was performed in 29 cases (3DCRT group) and 3DCRT combined with hyperthermia in 24 cases (3DCRT combined with hyperthermia group). After treatment, statistical analysis of the two groups of clinical efficacy and radiotherapy differences, and analysis of the relationship between the number of microwave hyperthermia and curative effect. Results: The effective rate was 72.41% in 3DCRT group, 83.33% in 3DCRT combined hyperthermia group, 90.00% in microwave hyperthermia group ≥ 4 times, and 75.00% in 4 times. In the recent response of radiation complication, The incidence of rectal reaction in 3DCRT group was 37.9%, that in 3DCRT combined with hyperthermia group was 29.2%, that in 3DCRT group was 17.2%, and that in 3DCRT combined with hyperthermia group was 12.5%. In long-term radiotherapy, 3DCRT The incidence of mild and moderate radiation proctitis was 13.8%, and that of 3DCRT combined with hyperthermia was 8.3%. The incidence of radiation cystitis was 10.3% in 3DCRT group and 8.3% in 3DCRT combined with hyperthermia group. The difference between the two groups was significant (P <0.05). Conclusion: 3DCRT combined with hyperthermia can effectively control tumor development and control radiation complications more effectively. The frequency of microwave treatment is positively correlated with the curative effect.