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Seven novel spin labeled derivatives of 4′-demethyl-4-deoxypodophyllotoxin with nitroxyl radicals(TMHPO and TMPRO) were prepared and their cytotoxic and antioxidative activities were tested. Their cytotoxic activities were tested against two tumor cell lines(A-549 and HL-60) in vitro. Among them, five compounds show higher inhibition activity against A-549 cells compared with the clinical drug VP-16(2) and parent compound 4′-demethyl-4-deoxypodophyllotoxin(DDPT, 6). Compounds 8, 10 and 13 show excellent inhibition activity against HL-60 cells. Furthermore, the antioxidative activities of them were tested. All the seven spin labeled compounds show stronger antioxidative activity compared with VP-16(2) and DDPT(6). The partition coefficients P of these derivatives were determined.
Seven novel spin-labeled derivatives of 4’-demethyl-4-deoxypodophyllotoxin with nitroxyl radicals (TMHPO and TMPRO) were prepared and their cytotoxic and antioxidant activity were tested. Their cytotoxic activities were tested against two tumor cell lines (A-549 and HL- 60) in vitro. Among them, five compounds show higher inhibition activity against A-549 cells compared with the clinical drug VP-16 (2) and parent compound 4’-demethyl- 4-deoxypodophyllotoxin (DDPT, All the seven spin-labeled compounds show superior antioxidative activity compared with VP-16 (2) and DDPT (6). The partition coefficients P of these derivatives were determined.