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目的探讨阿托伐他汀强化降脂对急性脑梗死患者疗效与炎症因子的影响。方法 96例急性脑梗死患者,随机分为研究组与对照组,各48例。在常规治疗的基础上,对照组应用常规剂量阿托他汀钙片治疗,研究组应用强化剂量阿托伐他汀治疗。对比两组疗效。结果研究组总有效率93.75%高于对照组79.17%(χ2=4.360,P<0.05)。研究组治疗后白细胞介素-10(IL-10)高于对照组,肿瘤坏死因子-α(TNF-α)与超敏C反应蛋白(hs-CRP)低于对照组(P<0.05)。结论阿托伐他汀强化降脂在急性脑梗死患者中应用效果显著,可以有效抑制炎性因子,促使神经功能恢复,适于临床推广。
Objective To investigate the effects of atorvastatin on lipid lowering in patients with acute cerebral infarction and the effect of inflammatory factors. Methods 96 patients with acute cerebral infarction were randomly divided into study group and control group, 48 cases in each. On the basis of routine treatment, the control group was treated with conventional dose of atorvastatin calcium, and the study group was given booster dose of atorvastatin. Compare two groups curative effect. Results The total effective rate in study group was 93.75% higher than 79.17% in control group (χ2 = 4.360, P <0.05). The levels of interleukin-10 (IL-10) in the study group were higher than those in the control group, and the levels of tumor necrosis factor-α (TNF-α) and hs-CRP were lower in the study group than those in the control group (P <0.05). Conclusions Atorvastatin is an effective lipid-lowering therapy in patients with acute cerebral infarction. It can inhibit inflammatory cytokines and promote neurological recovery, which is suitable for clinical application.