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直肠用药途径的特点直肠用药,曾以治疗痔疮为主,以其局部作用为目的。1950年以后,将直肠作为向全身循环系统投药途径的研究越来越多。且因肌注抗菌药物和解热镇痛药物多发生肌肉挛缩等后遗症,故临床上以全身作用为目的的直肠用药,也被重新重视起来。结果,将解热镇痛剂、支气管扩张剂、非类固醇类抗炎剂、抗恶性肿瘤剂、镇吐剂、抗生素等以坐剂提供给临床。作为药物剂型。除坐药增多外,也和赋型剂的进步,物理性质的改良有关。坐剂在直肠内软化溶解后,主药向直肠分泌液中释放、溶解,溶解的主药按着非解离分子种类的油水
The characteristics of the rectal route of rectal medication, once used to treat hemorrhoids, with its local role for the purpose. Since 1950, there has been a growing body of research into the rectum as a route of administration to the systemic circulatory system. And because of intramuscular antibacterial drugs and antipyretic analgesics and more sequelae of muscle contracture, so the clinical role of rectal for the purpose of rectal medication has also been re-emphasized. As a result, antipyretic analgesics, bronchodilators, non-steroidal anti-inflammatory agents, antineoplastic agents, antiemetic agents, antibiotics and other sedatives are provided to the clinic. As a pharmaceutical dosage form. In addition to the increase of sitting medicine, but also with the improvement of excipients, the physical properties of the improvement. Sitting agent in the rectum to soften dissolved, the main drug release to the rectal secretion, dissolution, dissolution of the main drug according to non-dissociative molecular species of oil and water