胰岛素具有降血糖作用,一直作为糖尿病的重要治疗药品,但因在消化道受蛋白水解酶的作用失活,难以口服给药,而需长期注射治疗,给患者造成精神与肉体上的痛苦,对医生也带来较大负担。为克服上述困难,近些年来,有人将胰岛素、水、橄榄油、表面活性剂(聚氧乙烯油酸酯)等研制直肠给药剂型。但由于胰岛素在肠道的吸收性差,给药量势必远大于注射剂的用量,不但造成浪费,而且难以控制正常给药,万一吸收超量,就有引起血糖过份降低的危险,因此难达有效与安全的目的。本发明针对上述注射给药的困难和直肠给 Insulin has a hypoglycemic effect, has been used as an important therapeutic drug for diabetes, but because of the digestive tract by the proteolytic enzyme inactivation, it is difficult to orally administered, but long-term injection therapy, mental and physical pain caused to the patient, Doctors also bring a greater burden. In order to overcome these difficulties, in recent years, insulin, water, olive oil, surfactant (polyoxyethylene oleate) and the like have been developed for rectal administration. However, due to poor absorption of insulin in the intestine, dosage is bound to much greater than the amount of injection, not only waste, but also difficult to control the normal administration, in case of excessive absorption, there is the risk of causing excessive blood glucose reduction, it is difficult to reach Effective and safe purpose. The present invention addresses the above-mentioned difficulty of administration by injection and rectal administration