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目的 探讨小儿大肠埃希菌和肺炎克雷伯菌超广谱β-内酰胺酶(ESLBs)的耐药情况及防治措施。方法 对51例小儿患者细菌培养为大肠埃希菌和肺炎克雷伯菌的药物敏感率,结合临床综合分析。结果 有27例患儿为ESLBs阳性,药物敏感率高低依次为亚胺硫霉素、丁胺卡那霉素、哌拉西林/他唑巴坦(piperacillin/tazobactoam)、环丙氟哌酸、头孢西丁,这五种抗生素药物敏感率依次为96.3%、74.1%、70.4%、63.0%和55.%。其他抗生素敏感率均在25.9%以下。应用头孢曲松钠(菌必治)者细菌产ESLBs明显多于不用菌必治者(P<0.01)。结论 对ESLBs阳性细菌的感染首选亚胺硫霉素。不滥用抗生素,严格做好消毒隔离预防措施。
Objective To investigate the drug resistance of Escherichia coli and Klebsiella pneumoniae ESBLs in children and its prevention and treatment. Methods 51 cases of pediatric patients with bacterial culture Escherichia coli and Klebsiella pneumoniae drug sensitivity, combined with clinical analysis. Results A total of 27 children were positive for ESLBs. The drug sensitivity rates were as follows: Imipenem, Amikacin, Piperacillin / Tazobactam, Ciprofloxacin, The sensitivity of these five antibiotics was 96.3%, 74.1%, 70.4%, 63.0% and 55.%, respectively. The sensitivity of other antibiotics are below 25.9%. The application of ceftriaxone sodium (bacteria will rule) bacteria ESLBs produced significantly more than those who do not need bacteria to rule (P <0.01). Conclusion Infections of ESLBs-positive bacteria are the first choice of imipenem. Do not abuse antibiotics, strict disinfection and isolation precautions.