论文部分内容阅读
目的:分析化疗、放疗、化疗即三明治法综合治疗食管癌的临床疗效并与单纯放疗进行比较.方法:1995年4月至1997年10月对食管癌综合治疗与单纯放疗进行随机分组研究.两组病例均为38例.两组放疗方法和剂量相同,每次1.8～2.0Gy,每周五次,总量达DT65Gy左右/6.5～7周.综合组所用化疗方案DDP、5-FU、PYN,放疗前、后一周各行一疗程化疗.结果:综合组临床疗效CR39.5%(15/38),PR 50%(19/38),NC 5.3%(2/38)和PD 5.3%(2/38),有效率(CR+PR)89.5%(34/38).单放组CR13.2%(5/38),PR 36.8%(14/38),NC 36.8%(14/38)和PD 13.2%(5/38),有效率(CR+PR)50%(19/38).综合组的CR及有效率均优于单放组.(P<0.05).结论:对食管癌进行综合治疗能提高临床疗效.
OBJECTIVE: To analyze the clinical efficacy of chemotherapy, radiotherapy and chemotherapy combined with sandwiches for the treatment of esophageal cancer and compare it with radiotherapy alone. METHODS: From April 1995 to October 1997, randomized subgroups of esophageal cancer combined therapy and radiotherapy alone were performed. There were 38 cases in each group. The two groups had the same radiotherapy method and dose, 1.8-2.0Gy each time, five times per week, and the total amount was about DT65Gy / 6.5-7 weeks. The chemotherapy group used in the comprehensive group was DDP, 5-FU, PYN. , One course of chemotherapy before and after radiotherapy. Results: Clinical efficacy of the comprehensive group CR39.5% (15/38), PR 50% (19/38), NC 5.3% (2/38) and PD 5.3% (2 /38), The effective rate (CR+PR) was 89.5% (34/38). The radiotherapy group had CR 13.2% (5/38), PR 36.8% (14/38), NC 36.8% (14/38) and PD 13.2% (5/38), effective rate (CR+PR) 50% (19/38). The CR and effective rate of the comprehensive group were better than that of the radiotherapy group (P<0.05). Conclusion: For esophageal cancer Comprehensive treatment can improve clinical efficacy.