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目的探讨综合治疗食管癌的临床疗效并与单纯放疗进行比较。方法７２例初次治疗的食管癌患者随机分为综合治疗组和单纯放疗组。综合组所用化疗方案为顺铂（ＤＤＰ）、５－氟脲嘧啶（５－Ｆｕ），放疗前化疗２个周期，放疗后化疗１个周期。两组放疗方法和剂量相同，每次１．８～２．０ＧＹ，１ｗｋ５次，总量达ＤＴ６５Ｇｙ左右／６．５～７ｗｋ。结果综合组临床疗效ＣＲ４１．７％（１５／３６），ＰＲ４４．４％（１６／３６），有效率（ＣＲ＋ＰＲ）８６．１％（３１／３６）；单纯放疗组ＣＲ１３．９％（５／３６），ＰＲ４１．７％（１５／３６），ＣＲ＋ＰＲ５５．６％（２０／３６）。综合组ＣＲ及有效率均优于单纯放疗组（Ｐ＜０．０５）。结论综合治疗食管癌能提高临床疗效。
Objective To explore the clinical efficacy of comprehensive treatment of esophageal cancer and compare it with radiotherapy alone. Methods Seventy-two esophageal cancer patients who were initially treated were randomly divided into a comprehensive treatment group and a single radiotherapy group. The chemotherapy regimens used in the comprehensive group were cisplatin (DDP), 5-fluorouracil (5-Fu), 2 cycles of chemotherapy before radiotherapy, and 1 cycle of chemotherapy after radiotherapy. The two groups of radiotherapy methods and doses were the same, each time 1.8 ~ 2.0GY, 1wk5 times, the total amount of about DT65Gy / 6.5 ~ 7wk. Results In the comprehensive group, the clinical curative effect was 41.7% (15/36), PR 44.4% (16/36), and the effective rate (CR+PR) was 86.1% (31/36); the radiotherapy group had CR 13.9% (5/ 36), PR 41.7% (15/36), CR+PR 55.6% (20/36). The CR and effective rate of the comprehensive group were better than those of the single radiotherapy group (P<0.05). Conclusion Comprehensive treatment of esophageal cancer can improve clinical efficacy.