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目的 将脑梗死纳络酮即刻效应与体感诱发电位 (SEP)脑功能评价法相结合 ,以探讨脑梗死的神经功能变化和纳洛酮对其的影响。方法 结合临床和影像资料 ,动态分析纳洛酮治疗脑梗死前后的SEP表现。结果 皮层电位N2 0 未引出的责任病灶 ,一是丘脑梗死 ,二是放射冠和顶叶梗死 ;N2 0 再现与纳洛酮药效相一致 ;纳洛酮对脑梗死的影响 ,与改善神经传导功能相比 ,主要是提高大脑神经元兴奋性。结论 SEP既是评价脑梗死纳洛酮即刻疗效的客观、敏感方法 ,又可用于探讨纳洛酮作用机制
Objective To combine the instantaneous effect of naloxone in cerebral infarction with the evaluation of brain function of somatosensory evoked potential (SEP) to explore the neurological changes of cerebral infarction and the effect of naloxone on it. Methods The clinical and imaging data were used to analyze the SEP manifestations of naloxone before and after cerebral infarction. The results of cortical potential N2 0 did not lead to the responsibility of the lesion, first, thalamic infarction, the second is the radial crown and parietal infarction; N2 0 reproduction consistent with the efficacy of naloxone; naloxone on cerebral infarction, and improve nerve conduction Compared with the function, the main is to increase the excitability of brain neurons. Conclusions SEP is not only an objective and sensitive method to evaluate the immediate curative effect of naloxone on cerebral infarction, but also can be used to explore the mechanism of action of naloxone