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β-受体阻滞剂长期应用能否降低心肌梗塞后的猝死率,颇有争论.各次研究结果的不一,究竟是由于病例选择、样本大小和药物应用时间长短的不同,还是β-受体阻滞剂的药理特性所致,一直不太清楚.本文应用心得安治疗“高度危险”的心肌梗塞后患者一年,观察这些患者的死亡率是否有降低.方法:从1977年12月起至1980年7月,在挪威12所医院的重点监护病房中,按WHO标准确诊为急性心肌梗塞的患者共4,929例.其中574例(11.6%)在随机分组前死亡,大多死于心源性休克.
Long-term use of β-blockers can reduce the rate of sudden death after myocardial infarction, quite controversial.Each study results are different, is due to case selection, sample size and the length of time the drug is different, or β- Receptor blockers due to the pharmacological properties has been less clear .This application of propranolol “highly dangerous” after a year of myocardial infarction, to observe whether these patients have reduced mortality.Methods: From 1977 From December to July 1980, 4,929 patients with acute myocardial infarction were diagnosed as having acute myocardial infarction in 12 hospitals in 12 Norwegian hospitals, 574 (11.6%) died prior to randomization and most died Cardiogenic shock.