1976年Rowley等报道1例血小板增多和3号同源染色体插入易位的急性粒-单核细胞白血病。因而有人设想3号染色体长臂上有一个区可能与血小板生成的调控有关。本文报道3例伴有巨核细胞和血小板异常的急性非淋巴细胞白血病(ANLL)均有未曾报道过的明显一致的3号染色体长臂的倒位,同时报道另1例异常血小板生成的ANLL有和Sweet等报道的病例相似的3号染色体长臂的异常,从而进一步间接证明3号染色体在血小板生成中的作用。 4例皆为男性,年龄在23～67岁。入院时病史和体检无一致发现,仅两例有出血倾向。所有4例的血 In 1976, Rowley et al. Reported a case of acute myelomonocytic leukemia with thrombocytosis and insertion of the homologous chromosome 3 in the translocation. Therefore, it is assumed that a region on the long arm of chromosome 3 may be related to the regulation of platelet production. This article reports 3 cases of acute non-lymphocytic leukemia (ANLL) accompanied by megakaryocytes and platelet abnormalities have not yet been reported in the obvious consistent long arm of chromosome 3 inversions, and another report of another case of abnormal platelet-producing ANLL and Sweet and other cases reported similar to the long arm of chromosome 3 anomalies, which indirectly indirectly prove the role of chromosome 3 in platelets. 4 cases are all men, aged 23 to 67 years old. No history of hospitalization and physical examination found that only two cases had bleeding tendency. All 4 cases of blood