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本文系研究消化系统某些自身免疫性疾病的免疫球蛋白异常。除测定患者血中各种免疫球蛋白水平外,还用外周血中的淋巴细胞体外培养,观察自发性和PWM刺激下各种免疫球蛋白的合成情况。结果表明:慢性肝病时常出现高免疫球蛋白血症,IgG、IgA和IgM均升高。体外淋巴细胞合成IgG、IgA常比正常者增多(P<0.01);在PWM刺激下合成的IgG和IgA更多(P<0.05)。溃疡性结肠炎,Crohn病及原发性胆汁性肝硬化患者血中免疫球蛋白升高者较少,体外淋巴细胞合成免疫球蛋白亦仅IgM稍多,而IgG和IgA则与正常人无明显差别,说明消化系统某些自身免疫性疾病的B细胞功能状态是各不相同的。
This article studies the immune globulin abnormalities in some autoimmune diseases of the digestive system. In addition to the determination of various immunoglobulin levels in patients with blood, but also with peripheral blood lymphocytes in vitro, spontaneous and PWM stimulation to observe the synthesis of a variety of immunoglobulins. The results show that: chronic immunodeficiency disease often occurs, IgG, IgA and IgM were elevated. IgG and IgA were more often expressed in lymphocytes than those in normal lymphocytes (P <0.01). More IgG and IgA were synthesized under the stimulation of PWM (P <0.05). Ulcerative colitis, Crohn’s disease and primary biliary cirrhosis patients with elevated serum immunoglobulin less lymphocyte synthesis of immunoglobulin IgM only slightly more, while IgG and IgA were normal and no significant Difference, indicating that some autoimmune diseases of the digestive system of B-cell functional status is different.