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为了探讨血清肌红蛋白 (myoglobin ,Mb)在急性心肌梗塞 (acutemyocardialinfarction ,AMI)时升高的时间特点及不同部位心肌梗塞之间水平的差异 ,我们测定了 4 0例AMI患者在 3～6小时、12小时、2 4小时和 4 8小时的Mb水平 ,同时测定了磷酸肌酸激酶 -MB(CK -MB)及乳酸脱氢酶 (LDH)。结果提示血清Mb在AMI患者发病 3～ 6小时即明显升高 (P <0 .0 1) ,阳性率已达 80 % ;12小时水平最高 ,阳性率已达 10 0 % ;而CK -MB和LDH的升高时间和峰值均迟于Mb。在四种不同部位梗塞患者中 ,以急性前壁梗塞患者血清Mb水平最高、持续时间最长 ,病死率最高 ;其次为非Q波型梗塞患者。结论表明 :对于那些发病早、临床症状和心电图不典型的AMI患者应尽早检测Mb ,以免贻误治疗时机。同时 ,Mb也可作为评估AMI预后和判定梗塞面积的一个良好指标
To investigate the time-dependent increase of serum myoglobin (Mb) in acute myocardial infarction (AMI) and the difference in myocardial infarction between different regions, we measured the percentage of patients with AMI in 3 to 6 hours , 12 hours, 24 hours and 48 hours respectively. Meanwhile, phosphocreatine creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) were measured. The results showed that serum Mb was significantly increased in AMI patients 3 to 6 hours after onset (P <0.01), the positive rate reached 80%, the highest level at 12 hours, the positive rate reached 10%; while CK-MB and LDH rise time and peak are later than Mb. Among the four different types of infarction patients, patients with acute anterior infarction had the highest serum Mb level, the longest duration and the highest case fatality rate, followed by those with non-Q wave infarction. Conclusion: For those with early onset, clinical symptoms and ECG atypical AMI patients should be detected Mb, so as not to delay the timing of treatment. At the same time, Mb can be used as a good indicator to evaluate the prognosis of AMI and determine infarct size