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锥体外系是人体运动系统的一个组成部分,由纹状体、黑质、红核、丘脑底核与顶盖网状核组成,其主要功能是调节肌张力、肌肉的协调运动与平衡,已知脑内有8条多巴胺(DA)能神经通路,其中黑质-纹状体DA能神经通路,是锥体外系运动功能的主要调控中枢,锥体外系功能有赖于该调控中枢中抑制性递质DA、5-羟色胺与兴奋性递质乙酰胆碱、组胺之间的动态平衡。抑制性神经元活性下降,兴奋性神经元活性增强,则引起震颤麻痹综合征、静坐不能、急性肌张力障碍等反应,反之则比现迟发性运动障
Extrapyramidal system is a part of the human body movement system, which consists of the striatum, substantia nigra, red nucleus, subthalamic nucleus and the top of the reticular nucleus, its main function is to regulate muscle tone, muscle coordination and balance, There are eight dopamine (DA) nerve pathways in the brain. Among them, the substantia nigra and striatal DA neurotransmission pathway is the main control center of extrapyramidal motor function. Extrapyramidal function depends on the inhibitory delivery Quality DA, 5-hydroxytryptamine and excitatory neurotransmitter acetylcholine, histamine dynamic balance between. Inhibitory neuronal activity decreased, excitatory neuronal activity increased, then cause paralysis paralysis syndrome, sedentary, acute dystonia and other reactions, and vice versa than the current delayed motor impairment