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背景对2009年流感大流行A H1N1病毒年龄免疫流行性和感染发病率加以认识,对模拟未来疾病负荷和免疫接种干预项的作用至关重要。方法 在本次血清学横向调查中,我们获得了2008年采集的1 403个血清标本(H1N1感染一波前),及2009年8月和9月采集1 954个血清学标本(感染一波后),属于英国健康防护局血清流行病学项目年度标本收集项,标本来自于英国医疗保健就诊病人。采用血球凝集抑制和微量中和测定法,做抗体滴度检测。我们计算了年龄组2008年H1N1大流行病毒抗体滴度样本比例,且将感染一波前、后血球凝集抑制滴度≥1∶32样本比例做了比较(确定有保护作用)。发现2008年基线血清样本,血球凝集抑制和微量中和抗体滴度随着年龄增长而增加(F检验,P<0.0001)。血球凝集抑制滴度≥1:32的标本比例范围:从0～4岁儿童1.8%[3/171;95%CI(0.6,5.0)]至年龄≥80岁成人31.3%[52/166;95%CI(24.8,38.7)]。伦敦和中英格兰西,基线和2009年9月之间,血球凝集抑制滴度≥1∶32的样本比例存在差异,<5岁儿童21.3%[95%CI(8.8,40.3)];5～14岁42.0%[95%CI(26.3,58.2)];15～24岁20.6%[95%CI(1.6,42.4)];年长组基线和9月间无差异。其他地区,仅<15岁儿童自基线水平有显著增高6.3%[95%CI(1.8,12.9)]。解释H1N1流行一波高发区每三个感染者有1名儿童,比临床监察评估要多10倍。老年人预存抗体可以预防感染。儿童在流感传播中有着重要角色,也为疫苗接种重要靶人群,通过群体免疫力,获得他们自身和其他人群的防护作用。
Background Knowledge of the age-related epidemic and infection rates of the 2009 H1N1 influenza A H1N1 virus is of crucial importance in modeling future effects of disease burden and immunization interventions. Methods In this serological horizontal survey, we obtained 1 403 serum samples (one wavefront of H1N1 infection) collected in 2008 and 1 954 serological samples collected in August and September 2009 ), Belonging to the annual collection of items from the British Bureau of Health Protection Serology Epidemiology, from specimens taken from healthcare providers in the United Kingdom. Using hemagglutination inhibition and micro-neutralization assay, do antibody titers. We calculated the proportion of the 2008 H1N1 pandemic virus antibody titers in the age group and compared the proportion of pre-infection and post-haemagglutination inhibition titers ≥ 1: 32 (determined to be protective). Baseline serum samples, hemagglutination inhibition and trace neutralizing antibody titers were found to increase with age (F test, P <0.0001) in 2008. Proportion of samples with hemagglutination inhibition titer ≥1: 32 ranged from 1.8% [3/171; 95% CI (0.6,5.0)] in children 0-4 years old to 31.3% [52/166; 95 % CI (24.8, 38.7)]. There was a difference in the proportion of samples with London, England and West-Central England, baseline hemagglutination inhibition titers ≥1: 32 between September 2009 and September 2009, 21.3% [95% CI (8.8, 40.3) 42.0% [95% CI (26.3,58.2)]; 20.6% [95% CI (1.6,42.4)] 15-24 years old; there was no difference between baseline and September in the elder group. Elsewhere, children <15 years of age had a significant 6.3% [95% CI (1.8,12.9)] increase from baseline. Explain that H1N1 is endemic in a wave of endemic areas with one child out of every three infected people, 10 times more than the clinical surveillance assessment. Pre-stored antibodies in the elderly can prevent infection. Children play an important role in the spread of influenza and are also important vaccines for targeted target populations, gaining protection from themselves and other populations through their immunity.