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1 神经生长因子概况 神经生长因子(NGF)研究是近年来神经科学中最活跃的领域之一。1948年Bucker用小鸡肉瘤180及肉瘤37匀浆接种培养鸡胚时发现其中有些物质能促使鸡胚的背根节变大。以后,Levi-Montalcini分析了这一物质,并提出这种能促进神经生长的物质称为NGF。1954年首次从组织中提取纯化了NGF蛋白,并证明NGF是神经系统发育和维持正常功能所必需的活性分子之一。70年代对NGF的认识主
1 Nerve growth factor profile Nerve growth factor (NGF) research in neuroscience in recent years, one of the most active areas. In 1948 Bucker with chick sarcoma 180 and sarcoma 37 homogenate inoculated culture of chicken embryos found that some of these substances can promote chicken embryo dorsal root enlargement. Later, Levi-Montalcini analyzed the substance and proposed that such a substance that promotes nerve growth is called NGF. Purified NGF protein from tissues for the first time in 1954 and proved that NGF is one of the active molecules necessary for nervous system development and normal function. The 1970s understanding of the main NGF