目的:探讨T-钙黏蛋白(T-cad)、血管内皮钙黏蛋白(VE-cad)与子宫腺肌病(AM)及子宫内膜异位症(EM)的关系。方法:收集中国人民解放军第一七五医院2010~2013年162例AM及EM住院手术患者的石蜡块,分为腺肌病组、异位囊肿组、子宫腺肌病合并卵巢子宫内膜异位囊肿组(合并组)各54例,另选择同期正常子宫内膜(对照组)54例,采用免疫组化SP二步法检测子宫腺肌病、卵巢子宫内膜异位囊肿、子宫腺肌病合并卵巢子宫内膜异位囊肿及正常子宫内膜Tcad与VE-cad表达,并进行相关性分析。结果:1腺肌病组、异位囊肿组和合并组在位内膜T-cad的表达率分别为11.11%(6/54)、3.70%(2/54)和11.11%(6/54),与对照组37.04%(20/54)比较差异有统计学意义(P<0.05);2腺肌病组、异位囊肿组、合并组腺肌病异位内膜、合并组卵巢异位内膜VE-cad的表达率分别为70.38%(38/54)、64.48%(35/54)、42.26%(23/54)和33.33%(18/54),差异有统计学意义(P<0.05);3异位囊肿组Ⅰ~Ⅱ期T-cad的表达率70.59%(12/17)高于Ⅲ~Ⅳ期的2.70%(1/37),差异有统计学意义(P<0.05),而合并组Ⅰ~Ⅱ期T-cad的表达率28.57%(4/14)高于Ⅲ~Ⅳ期的0.00%(0/40),差异有统计学意义(P<0.05);4 T-cad与VE-cad在各组子宫内膜的表达无相关性(P>0.05)。结论:T-cad在AM及EM内膜上表达低于正常内膜,而VE-cad在AM及EM内膜上表达较正常内膜升高,证明两者可能与AM及EM发病相关。 Objective: To investigate the relationship between T-cadherin, vascular endothelial cadherin (VE-cad) and adenomyosis (AM) and endometriosis (EM). Methods: A total of 162 paraffin blocks of AM and EM inpatients were collected from the 175th Hospital of People’s Liberation Army from 2010 to 2013. The paraffin blocks were divided into adenomyosis group, ectopic cyst group, adenomyosis with ovarian endometriosis 54 cases in the cyst group (combined group) and 54 cases in the normal endometrium (control group) during the same period. SP immunohistochemical method was used to detect adenomyosis, ovarian endometriosis cyst, adenomyosis Combined with ovarian endometriosis cyst and normal endometrial Tcad and VE-cad expression, and correlation analysis. Results: The expression of T-cad in eutopic endometrium in adenomyosis group, ectopic cyst group and combined group were 11.11% (6/54), 3.70% (2/54) and 11.11% (6/54), respectively , Compared with 37.04% (20/54) in the control group (P <0.05); 2 adenomyosis group, ectopic cyst group, adenomyosis group in the combined group, ectopic endometrium in the combined group The expression rates of VE-cad was 70.38% (38/54), 64.48% (35/54), 42.26% (23/54) and 33.33% (18/54) respectively, with significant difference (P <0.05 ). The positive rate of T-cadherin in stage Ⅰ-Ⅱ ectopic cyst was 70.59% (12/17), which was significantly higher than that in stage Ⅲ-Ⅳ (2.70%, 1/37) (P <0.05) The expression of T-cad in stage Ⅰ-Ⅱ was higher than that in stage Ⅲ-Ⅳ (28.57%, 4/14), with a significant difference (P0.05) There was no correlation between the expression of VE-cad and endometrium (P> 0.05). CONCLUSION: The expression of T-cad is lower than that of normal endometrium on AM and EM endometrium, while the expression of VE-cad is higher than that of normal endomembrane on AM and EM endometrium, demonstrating that both may be related to the pathogenesis of AM and EM.