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目的分析佛山地区女性人群人乳头瘤病毒(HPV)感染特点及基因亚型分布情况。方法收集15 867例标本,采用HPV基因分型技术进行23种亚型的分型检测。结果 15 867例受检者中,HPV总感染率为26.82%(4 256/15 867),以高危型为主18.71%(2 969/15 867)。HPV高危型感染率较高的亚型依次为HPV 52(7.13%)、HPV 16(3.55%)、HPV 58(2.53%),低危型感染率较高的是HPV 6(2.52%)。在感染型别中,单一感染、二重感染和多重感染率分别是18.68%(2 964/15 867)、5.29%(840/15 867)和2.85%(452/15 867)。<20岁年龄段为HPV感染的高峰期,不同年龄段的HPV感染率差异有统计学意义(χ~2=422.84,P<0.01)。结论佛山地区女性HPV的感染主要以单一型、高危型为主,最常见的HPV亚型依次是52、16、58。
Objective To analyze the characteristics and distribution of human papillomavirus (HPV) in Foshan female population. Methods A total of 15 867 specimens were collected and the genotypes of 23 subtypes were detected by HPV genotyping. Results Among 15 867 subjects, the total HPV infection rate was 26.82% (4 256/15 867), with high-risk type being 18.71% (2 969/15 867). The subtypes of high-risk HPV infection were HPV 52 (7.13%), HPV 16 (3.55%) and HPV 58 (2.53%), while HPV 6 (2.52%) was the most susceptible to low-risk infection. Among the infection types, the rates of single infection, double infection and multiple infection were 18.68% (2 964/15 867), 5.29% (840/15 867) and 2.85% (452/15 867), respectively. <20 years of age is the peak of HPV infection, HPV infection rates of different age groups were statistically significant (χ ~ 2 = 422.84, P <0.01). Conclusion The prevalence of HPV infection in Foshan area is mainly single type and high risk type. The most common HPV subtypes are 52, 16 and 58 in turn.