动物腺病毒具有与人腺病毒类似的基因组结构。近年来,通过缺失部分病毒基因并建立相应的互补细胞系,已构建成功犬、绵羊及牛腺病毒载体。这些新型动物腺病毒载体即可将外源基因转移到人体细胞内表达,本身又不能在其中复制繁殖,具有较高的安全性,人体内也不存在针对它们的免疫应答,因此可望替代人腺病毒作为基因治疗及基因免疫的载体。 Animal adenoviruses have a similar genomic structure as human adenoviruses. In recent years, successful canine, sheep and bovine adenoviral vectors have been constructed by deleting some of the viral genes and establishing corresponding complementary cell lines. These new animal adenoviral vectors can transfer exogenous genes into human cells for expression, and can not reproduce itself, which has high safety. There is no immune response against them in the human body, so it is expected to replace human Adenovirus as a vector for gene therapy and genetic immunization.