Based on the train-track coupling dynamics and high-speed train aerodynamics, this paper deals with an improved algorithm for fluid-structure interaction of high-speed trains. In the algorithm, the data communication between fluid solver and structure solver is avoided by inserting the program of train-track coupling dynamics into fluid dynamics program, and the relaxation factor concerning the load boundary of the fluid-structure interface is introduced to improve the fluctuation and convergence of aerodynamic forces. With this method, the fluid-structure dynamics of a highspeed train are simulated under the condition that the velocity of crosswind is 13.8 rn/s and the train speed is 350 km/h.When the relaxation factor equals 0.5, the fluctuation of aerodynamic forces is lower and its convergence is faster than in other cases. The side force and lateral displacement of the head train are compared between off-line simulation and co-simulation. Simulation results show that the fluid-structure interaction has a significant influence on the aerodynamics and attitude of the head train under crosswind conditions. In addition, the security indexes of the head train worsen after the fluid-structure interaction calculation. Therefore, the fluid-structure interaction calculation is necessary for high-speed trains.