采用薄膜水化法,以Span-60、胆固醇和磷脂为材料,制备了基于非离子表面活性剂的百里醌前体脂质体(thymoquinone proniosomal formulation),并考察其对甲氨蝶呤诱导的肝中毒模型大鼠的保肝作用。所得百里醌前体囊泡粒径为纳米级;包封率也较高,原因是百里醌具有亲脂性特性。外观结构表征结果显示制品呈球形,可见清晰的轮廓和核心,提示该密封载体结 The nonionic surfactant-based thymoquinone proniosomal formulation was prepared by the thin-film hydration method using Span-60, cholesterol and phospholipid as materials, and its effect on methotrexate-induced Hepatic Poisoning Model in Rats. The resulting particle size of the preglione precursor is nanoscale; the entrapment efficiency is also higher because of the lipophilic properties of the thioquinone. Characterization of the appearance of the structure showed that the product was spherical, showing a clear outline and core, suggesting that the sealed carrier junction